Folate:B12
Global tests
Type III ANOVA on main and interaction effects, and LM model summaries.
PRL (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
33.9677450
|
1
|
<0.0001
|
***
|
|
folate_B12
|
0.2922864
|
1
|
0.6
|
ns
|
|
Study
|
0.0030706
|
1
|
1.0
|
ns
|
|
GA_samp
|
20.0938411
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
0.9826171
|
1
|
0.3
|
ns
|
hPL (μg/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
6.6942890
|
1
|
0.010
|
*
|
|
folate_B12
|
4.6512349
|
1
|
0.03
|
*
|
|
Study
|
0.0693763
|
1
|
0.8
|
ns
|
|
GA_samp
|
323.6089803
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
4.1665896
|
1
|
0.04
|
*
|
GH2 (ng/ml)
|
|
Chisq
|
Df
|
Pr(>Chisq)
|
|
|
(Intercept)
|
24.247063
|
1
|
<0.0001
|
***
|
|
folate_B12
|
3.087119
|
1
|
0.08
|
ns
|
|
Study
|
2.290189
|
1
|
0.1
|
ns
|
|
GA_samp
|
96.394483
|
1
|
<0.0001
|
***
|
|
folate_B12:Study
|
2.838209
|
1
|
0.09
|
ns
|
Insulin (uU/ml)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.139
|
0.139
|
0.7
|
ns
|
|
3
|
Study
|
1
|
Inf
|
1.655
|
1.655
|
0.2
|
ns
|
|
4
|
GA_samp
|
1
|
Inf
|
0.991
|
0.991
|
0.3
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
0.164
|
0.164
|
0.7
|
ns
|
HOMA-IR
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
0.363
|
0.363
|
0.5
|
ns
|
|
3
|
Study
|
1
|
Inf
|
3.897
|
3.897
|
0.05
|
ns
|
|
4
|
GA_samp
|
1
|
Inf
|
0.502
|
0.502
|
0.5
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
0.043
|
0.043
|
0.8
|
ns
|
Glucose (mmol/L)
|
|
model term
|
df1
|
df2
|
F.ratio
|
Chisq
|
p.value
|
|
|
1
|
folate_B12
|
1
|
Inf
|
1.315
|
1.315
|
0.3
|
ns
|
|
3
|
Study
|
1
|
Inf
|
16.057
|
16.057
|
<0.0001
|
***
|
|
4
|
GA_samp
|
1
|
Inf
|
0.185
|
0.185
|
0.7
|
ns
|
|
2
|
folate_B12:Study
|
1
|
Inf
|
0.265
|
0.265
|
0.6
|
ns
|
Model summary
Ratio of Geometric means (95% CI)
PRL (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
14.82 (5.93, 36.94)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.33
|
|
StudySTOP
|
1.12 (0.82, 1.55)
|
0.48
|
|
GA_samp
|
1.13 (1.07, 1.20)
|
<0.0001
|
hPL (μg/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
1.96 (1.16, 3.25)
|
0.01
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.03
|
|
StudySTOP
|
1.03 (0.82, 1.30)
|
0.79
|
|
GA_samp
|
1.34 (1.29, 1.38)
|
<0.0001
|
|
folate_B12:StudySTOP
|
1.00 (1.00, 1.00)
|
0.04
|
GH2 (ng/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
0.16 (0.09, 0.32)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.61
|
|
StudySTOP
|
0.93 (0.73, 1.19)
|
0.56
|
|
GA_samp
|
1.22 (1.17, 1.27)
|
<0.0001
|
Insulin (uU/ml)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
17.79 (4.81, 65.85)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.48
|
|
StudySTOP
|
0.65 (0.41, 1.03)
|
0.07
|
|
GA_samp
|
1.04 (0.96, 1.13)
|
0.32
|
HOMA-IR
|
Var
|
Effect
|
P
|
|
(Intercept)
|
5.50 (1.36, 22.29)
|
0.02
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.37
|
|
StudySTOP
|
0.51 (0.31, 0.85)
|
0.009
|
|
GA_samp
|
1.03 (0.95, 1.13)
|
0.48
|
Glucose (mmol/L)
|
Var
|
Effect
|
P
|
|
(Intercept)
|
6.73 (5.15, 8.78)
|
<0.0001
|
|
folate_B12
|
1.00 (1.00, 1.00)
|
0.21
|
|
StudySTOP
|
0.79 (0.73, 0.86)
|
<0.0001
|
|
GA_samp
|
0.99 (0.97, 1.02)
|
0.65
|
Estimated means
Estimated marginal means (or adjusted means) adjusted for GA at sampling.
Results are averaged over the levels of Folate:B12 ratio and may be misleading when interaction term is involved.
PRL (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
71.60574
|
14.86257
|
52.74518
|
47.21980
|
108.5854
|
|
STOP
|
80.40635
|
13.27427
|
22.96752
|
57.14272
|
113.1409
|
hPL (μg/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
62.09345
|
4.870901
|
111.51851
|
53.15462
|
72.53548
|
|
STOP
|
73.39619
|
3.059959
|
29.65228
|
67.40274
|
79.92256
|
GH2 (ng/ml)
|
Study
|
response
|
SE
|
df
|
lower.CL
|
upper.CL
|
|
SCOPE
|
1.888354
|
0.2043171
|
133.89526
|
1.524561
|
2.338957
|
|
STOP
|
1.755293
|
0.0921474
|
39.51082
|
1.578531
|
1.951848
|
Insulin (uU/ml)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
28.59453
|
5.779733
|
Inf
|
19.24119
|
42.49462
|
|
STOP
|
18.55478
|
1.473926
|
Inf
|
15.87959
|
21.68065
|
HOMA-IR
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
7.759125
|
1.6807764
|
Inf
|
5.074883
|
11.863134
|
|
STOP
|
3.995353
|
0.3419368
|
Inf
|
3.378363
|
4.725025
|
Glucose (mmol/L)
|
Study
|
response
|
SE
|
df
|
asymp.LCL
|
asymp.UCL
|
|
SCOPE
|
6.134155
|
0.2493014
|
Inf
|
5.664487
|
6.642765
|
|
STOP
|
4.863797
|
0.1061501
|
Inf
|
4.660134
|
5.076361
|
Comparisons
Effect for every 100 unit increase in Folate:B12 ratio.
|
Hormone
|
Contrast
|
Study
|
Ratio of Geometric means (95% CI)
|
P-value
|
|
PRL (ng/ml)
|
folate_B12241.85 / folate_B12141.85
|
SCOPE
|
1.02 (0.98, 1.07)
|
0.3
|
|
PRL (ng/ml)
|
folate_B12241.85 / folate_B12141.85
|
STOP
|
1.02 (0.98, 1.07)
|
0.3
|
|
hPL (μg/ml)
|
folate_B12241.85 / folate_B12141.85
|
SCOPE
|
0.93 (0.88, 0.99)
|
0.03
|
|
hPL (μg/ml)
|
folate_B12241.85 / folate_B12141.85
|
STOP
|
1.00 (0.97, 1.03)
|
0.9
|
|
GH2 (ng/ml)
|
folate_B12241.85 / folate_B12141.85
|
SCOPE
|
0.99 (0.96, 1.03)
|
0.6
|
|
GH2 (ng/ml)
|
folate_B12241.85 / folate_B12141.85
|
STOP
|
0.99 (0.96, 1.03)
|
0.6
|
|
Insulin (uU/ml)
|
folate_B12241.85 / folate_B12141.85
|
SCOPE
|
0.98 (0.94, 1.03)
|
0.5
|
|
Insulin (uU/ml)
|
folate_B12241.85 / folate_B12141.85
|
STOP
|
0.98 (0.94, 1.03)
|
0.5
|
|
HOMA-IR
|
folate_B12241.85 / folate_B12141.85
|
SCOPE
|
0.98 (0.92, 1.03)
|
0.4
|
|
HOMA-IR
|
folate_B12241.85 / folate_B12141.85
|
STOP
|
0.98 (0.92, 1.03)
|
0.4
|
|
Glucose (mmol/L)
|
folate_B12241.85 / folate_B12141.85
|
SCOPE
|
0.99 (0.97, 1.01)
|
0.2
|
|
Glucose (mmol/L)
|
folate_B12241.85 / folate_B12141.85
|
STOP
|
0.99 (0.97, 1.01)
|
0.2
|
Diagnostics
Model diagnositcs.
Diagnositcs for PRL (ng/ml)
Diagnositcs for hPL (μg/ml)
Diagnositcs for GH2 (ng/ml)
Diagnositcs for Insulin (uU/ml)
Diagnositcs for HOMA-IR
Diagnositcs for Glucose (mmol/L)
